Diphenhydramine inhibits voltage-gated proton channels (Hv1) and induces acidification in leukemic Jurkat T cells- New insights into the pro-apoptotic effects of antihistaminic drugs-Reference-Cited by-同舟云学术

Diphenhydramine inhibits voltage-gated proton channels (Hv1) and induces acidification in leukemic Jurkat T cells- New insights into the pro-apoptotic effects of antihistaminic drugs

Published:2018-01-01 Issue:1 Volume:12 Page:58-64
ISSN:1933-6950
Container-title:Channels
language:en
Short-container-title:Channels

Author:

Asuaje Agustín¹,Martín Pedro¹,Enrique Nicolás¹,Zegarra Leandro Agustín Díaz¹,Smaldini Paola¹,Docena Guillermo¹,Milesi Verónica¹^ORCID

Affiliation:

1. Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP, CONICET—Universidad Nacional de la Plata), Fac. de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina

Funder

Agencia Nacional de Promoción Científica y Tecnológica, Argentina

Publisher

Informa UK Limited

Subject

Biochemistry,Biophysics

Link

https://www.tandfonline.com/doi/pdf/10.1080/19336950.2017.1331799

Reference27 articles.

1. Open channel block of NMDA receptors by diphenhydramine

2. Apoptosis of Human T-Cell Acute Lymphoblastic Leukemia Cells by Diphenhydramine, an H1 Histamine Receptor Antagonist

3. H1 histamine receptor antagonists induce genotoxic and caspase-2-dependent apoptosis in human melanoma cells

4. Terfenadine-induced apoptosis in human melanoma cells is mediated through Ca2+ homeostasis modulation and tyrosine kinase activity, independently of H1 histamine receptors

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