Affiliation:
1. Department of Chemistry Johannes Gutenberg University Mainz Duesbergweg 10–14 55128 Mainz Germany
2. Institute of Biological and Chemical Systems – Functional Molecular Systems (IBCS-FMS) Kaiserstrasse 12 76131 Karlsruhe Germany
Abstract
AbstractAn electrochemical multicomponent synthesis of sulfonamides at room temperature in single‐pass flow is presented. In contrast to batch‐type electrolysis, an undivided flow cell setup with a stainless‐steel cathode and either a boron‐doped diamond (BDD) anode or a glassy carbon anode can be employed. Simply by using SO2 stock solutions, less atom‐economic sulfur dioxide surrogates can be avoided. Moreover, no additional supporting electrolytes are required due to the in‐situ generation of amidosulfinates, which also serve as intermediate for this transformation. This protocol allows sulfonamides to be synthesized directly from non‐prefunctionalized electron‐rich arenes with amines and SO2. In total, 10 examples are demonstrated with isolated yields up to 92 %. The robust scalability of this electrosynthesis with an easy downstream processing was also proven.
Funder
Deutsche Forschungsgemeinschaft
Subject
Electrochemistry,Catalysis
Cited by
1 articles.
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