Application of a PEG precipitation method for solubility screening: A tool for developing high protein concentration formulations

Author:

Li Li1,Kantor Angela1,Warne Nicholas1

Affiliation:

1. Pharmaceutical Research and Development; BioTherapeutics Pharmaceutical Sciences, Pfizer; Andover Massachusetts

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Reference17 articles.

1. Challenges in the development of high protein concentration formulations;Shire;J Pharm Sci,2004

2. The new pre-preclinical paradigm: compound optimization in early and late phase drug discovery;Caldwell;Curr Top Med Chem,2001

3. Determination of the apparent thermodynamic activities of saturated protein solutions;Middaugh;J Biol Chem,1979

4. Fractionation of proteins and viruses with polyethylene glycol;Juckes;Biochim Biophys Acta,1971

5. The precipitation of enzymes from cell extracts of Saccharomyces cerevisiae by polyethylene-glycol;Foster;Biochem Biophys Acta,1973

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