Exploring semantic verbal fluency patterns and their relationship to age and Alzheimer's disease in adults with Down syndrome

Author:

Mgaieth Farah1ORCID,Baksh R. Asaad12,Startin Carla M.1234,Hamburg Sarah2,Hithersay Rosalyn123,Pape Sarah15,Zetterberg Henrik678910,Ashton Nicholas J.561112,Tamayo‐Elizalde Miren1,Saini Fedal1,Idris Mina1,Consortium The LonDownS2,Strydom Andre1235

Affiliation:

1. Department of Forensic and Neurodevelopmental Sciences Institute of Psychiatry Psychology & Neuroscience King's College London London UK

2. The LonDownS Consortium London UK

3. Division of Psychiatry University College London London UK

4. School of Psychology University of Roehampton London UK

5. South London and Maudsley NHS Foundation Trust London UK

6. Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg Mölndal Sweden

7. Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden

8. Department of Neurodegenerative Disease UCL Institute of Neurology London UK

9. UK Dementia Research Institute at UCL London UK

10. Hong Kong Center for Neurodegenerative Diseases Hong Kong China

11. Institute of Psychiatry Psychology and Neuroscience Maurice Wohl Institute Clinical Neuroscience Institute King's College London London UK

12. Centre for Age‐Related Medicine Stavanger University Hospital Stavanger Norway

Abstract

AbstractIntroductionAdults with Down syndrome (DS) are at ultra‐high risk of developing Alzheimer's disease (AD), characterized by poor episodic memory and semantic fluency in the preclinical phase in the general population. We explored semantic fluency performance in DS and its relationship to age, AD, and blood biomarkers.MethodsA total of 302 adults with DS at baseline and 87 at follow‐up from the London Down Syndrome Consortium cohort completed neuropsychological assessments. Blood biomarkers were measured with the single molecule array technique in a subset of 94 participants.ResultsPoorer verbal fluency performance was observed as age increases. Number of correct words declined in those with AD compared to those without over 2 years and was negatively correlated with neurofilament light (r = –0.37, P = .001) and glial fibrillary acidic protein (r = –0.31, P = .012).DiscussionSemantic fluency may be useful as an early indicator of cognitive decline and provide additional information on AD‐related change, showing associations with biomarkers in DS.

Funder

Medical Research Council

Alzheimer's Society

Fondation Jérôme Lejeune

European Commission

Stiftelsen för Gamla Tjänarinnor

UK Dementia Research Institute

Hjärnfonden

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

Reference47 articles.

1. The population prevalence of Down's syndrome in England and Wales in 2011;Wu J;Eur J Hum Genet,2013

2. Foundation GDS.Facts and FAQ About Down Syndrome.2019. Accessed May 1 2021.https://www.globaldownsyndrome.org/about‐down‐syndrome/facts‐about‐down‐syndrome/(2019)

3. A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome;Wiseman FK;Nat Rev Neurosci,2015

4. A prospective 20‐year longitudinal follow‐up of dementia in persons with Down syndrome;Mccarron M;J Intellect Disabil Res,2017

5. Predictors of age of diagnosis and survival of Alzheimer's disease in down syndrome;Sinai A;J Alzheimers Dis,2018

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