Imaging integrin alpha-v-beta-3 expression in tumors with an18F-labeled dimeric RGD peptide

Author:

Dijkgraaf Ingrid1,Terry Samantha Y. A.2,McBride William J.3,Goldenberg David M.3,Laverman Peter2,Franssen Gerben M.2,Oyen Wim J. G.2,Boerman Otto C.2

Affiliation:

1. Department of Biochemistry, Cardiovascular Research Institute; Maastricht University; Maastricht; The Netherlands

2. Department of Nuclear Medicine; Radboud University Nijmegen Medical Centre; Nijmegen; The Netherlands

3. Immunomedics Inc; Morris Plains; New Jersey; USA

Publisher

Wiley

Subject

Radiology Nuclear Medicine and imaging

Reference40 articles.

1. New perspectives in cell adhesion: RGD and integrins;Ruoslahti;Science,1987

2. Stereoisomeric peptide libraries and peptidomimetics for designing selective inhibitors of the alpha(V)beta(3) integrin for a new cancer therapy;Haubner;Angew Chem Int Edn,1997

3. Noninvasive imaging of alpha(v)beta3 integrin expression using 18F-labeled RGD-containing glycopeptide and positron emission tomography;Haubner;Cancer Res,2001

4. Biodistribution and pharmacokinetics of the alphavbeta3-selective tracer 18F-galacto-RGD in cancer patients;Beer;J Nucl Med,2005

5. Noninvasive visualization of the activated alpha v beta 3 integrin in cancer patients by positron emission tomography and [F-18]Galacto-RGD;Haubner;PLoS Med,2005

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