Affiliation:
1. Radiation Application
Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
2. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Abstract
Abstract:
Angiogenesis phenomenon, as a highly affecting factor on the growth and spread of
cancer cells, depends on specific molecular interactions between components of the extracellular
matrix and vascular cells. αv integrin acts as a cell adhesive molecule involved in tumor invasion
and angiogenesis. Among the various combinations of integrin subunits expressed on the surface
of cells, αvβ3 integrin has a particularly interesting expression pattern during angiogenesis. The
αvβ3 integrin is a vital receptor affecting tumor growth, tumor invasiveness, metastasis, and angiogenesis
overexpressed on various human tumors, leading to the development of different
theranostics probes and radiopharmaceuticals. The αvβ3 integrin can recognize several extracellular
matrix molecules in the base of the RGD adhesive sequence. This review provides an overview
of the status, trends and future of the most studied αvβ3 integrin-binding ligand, RGD tripeptides,
labeled with various radioisotopes. An overview of the pre-clinical models for radiolabeled RGD
peptides and clinical aspects of the RGD- based radiopharmaceuticals is provided with some new
considerations and ways forward.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Radiology, Nuclear Medicine and imaging