Determining the isotopic abundance of a labeled compound by mass spectrometry and how correcting for natural abundance distribution using analogous data from the unlabeled compound leads to a systematic error-Reference-Cited by-同舟云学术

Determining the isotopic abundance of a labeled compound by mass spectrometry and how correcting for natural abundance distribution using analogous data from the unlabeled compound leads to a systematic error

Published:2016-02-24 Issue:4 Volume:59 Page:136-146
ISSN:0362-4803
Container-title:Journal of Labelled Compounds and Radiopharmaceuticals
language:en
Short-container-title:J. Label Compd. Radiopharm

Author:

Schenk David J.¹,Lockley William J. S.²,Elmore Charles S.³,Hesk Dave¹,Roberts Drew⁴

Affiliation:

1. Department of Process and Analytical Chemistry; Merck Research Laboratories, Merck & Co., Inc.; Rahway NJ USA

2. Department of Chemistry; University of Surrey; Guildford Surrey UK

3. Isotope Chemistry, DMPK, Drug Safety and Metabolism, AstraZeneca; Mölndal Sweden

4. High Performance Computing, Informatics IT (Rahway); Merck & Co., Inc.; Rahway NJ USA

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Radiology Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/jlcr.3370/fullpdf

Reference21 articles.

1. Mass isotopomer analysis: Theoretical and practical considerations

2. IsoCor: correcting MS data in isotope labeling experiments

3. Measurement of the Isotope Enrichment of Stable Isotope-Labeled Proteins Using High-Resolution Mass Spectra of Peptides

4. A Computational Framework for High-Throughput Isotopic Natural Abundance Correction of Omics-Level Ultra-High Resolution FT-MS Datasets

5. Isotopomer distribution computation from tandem mass spectrometric data with overlapping fragment spectra

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