Bifunctionalized isotopologs as calibrants for standard‐free quantitation of drug metabolites in plasma by liquid chromatography coupled with radiometry and mass spectrometry-Reference-Cited by-同舟云学术

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Bifunctionalized isotopologs as calibrants for standard‐free quantitation of drug metabolites in plasma by liquid chromatography coupled with radiometry and mass spectrometry

Published:2021-10-03 Issue:1 Volume:36 Page:
ISSN:0269-3879
Container-title:Biomedical Chromatography
language:en
Short-container-title:Biomedical Chromatography

Author:

Gong Yong¹^ORCID,Chen Jie¹,Lim Heng‐Keang¹,Weng Naidong¹,Salter Rhys¹

Affiliation:

1. Drug Metabolism and Pharmacokinetics, Discovery Sciences Janssen Research and Development, Johnson & Johnson Spring House PA USA

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bmc.5242

Reference28 articles.

1. Absolute quantification of imipramine and its metabolites in vivo utilizing calibrators from radiolabeled in vitro incubations

2. Simultaneous quantification of acetaminophen and structurally related compounds in human serum and plasma

3. Simultaneous quantification of acetaminophen and five acetaminophen metabolites in human plasma and urine by high-performance liquid chromatography–electrospray ionization–tandem mass spectrometry: Method validation and application to a neonatal pharmacokinetic study

4. Use of relative 12C/14C isotope ratios to estimate metabolite concentrations in the absence of authentic standards

5. Stable isotope-labelled intravenous microdose for absolute bioavailability and effect of grapefruit juice on ibrutinib in healthy adults

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