Decision-making in early clinical drug development

Author:

Frewer Paul1,Mitchell Pat1,Watkins Claire2,Matcham James1

Affiliation:

1. Early Clinical Development Biometrics; AstraZeneca; Royston UK

2. Clarostat Consulting Ltd.; Alderley Edge UK

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology,Statistics and Probability

Reference8 articles.

1. Trial Watch: Phase II and Phase III attrition rates 2011-2012;Arrowsmith;Nature Reviews Drug Discovery,2013

2. A decade of innovation in pharmaceutical R&D: the Chorus model;Owens;Nature Reviews Drug Discovery,2015

3. Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework;Cook;Nature Reviews Drug Discovery,2014

4. A quantitative process for enhancing end of phase 2 decisions;Sabin;Statistics in Biopharmaceutical Research,2014

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