Affiliation:
1. School of Chemistry and Chemical Engineering Henan Normal University Xinxiang 453000 P. R. China
2. Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science Soochow University Suzhou 215123 P. R. China
Abstract
AbstractA novel, direct Csp3−Csp3 coupling reaction of β‐chlorophenone with alkanes using 2‐(tert‐butylperoxy)‐2‐methylpropane (DTBP) as the oxidant and 2,2′‐bipyridine (bpy) as the effective additive was developed. A variety of β‐chloropropiophenones were well tolerated, and afforded alkylated products in moderate to good yields. A mechanistic study indicated a free radical pathway was involved in this alkyl‐alkyl cross‐coupling reaction.
Funder
National Natural Science Foundation of China
Subject
General Chemistry,Biochemistry,Organic Chemistry