Pharmacological characterization of a novel potent, selective, and orally active phosphodiesterase 10A inhibitor, PDM‐042 [( E )‐4‐(2‐(2‐(5,8‐dimethyl‐[1,2,4]triazolo[1,5‐ a ]pyrazin‐2‐yl)vinyl)‐6‐(pyrrolidin‐1‐yl)pyrimidin‐4‐yl)morpholine] in rats: potential for the treatment of schizophrenia-Reference-Cited by-同舟云学术

Pharmacological characterization of a novel potent, selective, and orally active phosphodiesterase 10A inhibitor, PDM‐042 [( E )‐4‐(2‐(2‐(5,8‐dimethyl‐[1,2,4]triazolo[1,5‐ a ]pyrazin‐2‐yl)vinyl)‐6‐(pyrrolidin‐1‐yl)pyrimidin‐4‐yl)morpholine] in rats: potential for the treatment of schizophrenia

Published:2016-06-10 Issue:4 Volume:4 Page:
ISSN:2052-1707
Container-title:Pharmacology Research & Perspectives
language:en
Short-container-title:Pharmacol Res Perspect

Author:

Arakawa Keita¹,Maehara Shunsuke¹,Yuge Natsuko¹,Ishikawa Makoto²,Miyazaki Yutaka²,Naba Hiroyasu³,Kato Yutaka¹,Nakao Kazunari⁴

Affiliation:

1. Biology Laboratory Discovery Research Mochida Pharmaceutical Co., Ltd Shizuoka Japan

2. Medicinal Chemistry Laboratory Discovery Research Mochida Pharmaceutical Co., Ltd. Shizuoka Japan

3. Pharmacokinetics and Safety Laboratory Discovery Research Mochida Pharmaceutical Co., Ltd. Shizuoka Japan

4. Head of Discovery Research Discovery Research Mochida Pharmaceutical Co., Ltd. Shizuoka Japan

Funder

Mochida Pharmaceutical Company

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.241

Reference30 articles.

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3. Disturbed glucose metabolism among patients taking olanzapine and typical antipsychotics;Dunlop BW;Psychopharmacol Bull,2003

4. Striatum- and testis-specific phosphodiesterase PDE10A

5. Effects of zotepine, haloperidol and clozapine on MK-801-induced stereotypy and locomotion in rats

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