Affiliation:
1. Organic and Carbon Nanomaterials Unit Okinawa Institute of Science and Technology Graduate University 1919‐1 Tancha, Onna‐son, Kunigami‐gun Okinawa 904‐0495 Japan
2. College of Pharmaceutical Sciences Soochow University Suzhou 215123 P. R. China
3. Max Planck Institute for Polymer Research Ackermannweg 10 55128 Mainz Germany
4. Department of Chemistry University of Oxford Chemistry Research Laboratory Oxford OX1 3TA UK
Abstract
AbstractPhotoacoustic imaging (PAI)‐guided photothermal therapy (PTT) in the second near‐infrared (NIR‐II, 1000–1700 nm) window has been attracting attention as a promising cancer theranostic platform. Here, it is reported that the π‐extended porphyrins fused with one or two nanographene units (NGP‐1 and NGP‐2) can serve as a new class of NIR‐responsive organic agents, displaying absorption extending to ≈1000 and ≈1400 nm in the NIR‐I and NIR‐II windows, respectively. NGP‐1 and NGP‐2 are dispersed in water through encapsulation into self‐assembled nanoparticles (NPs), achieving high photothermal conversion efficiency of 60% and 69%, respectively, under 808 and 1064 nm laser irradiation. Moreover, the NIR‐II‐active NGP‐2‐NPs demonstrated promising photoacoustic responses, along with high photostability and biocompatibility, enabling PAI and efficient NIR‐II PTT of cancer in vivo.
Funder
Okinawa Institute of Science and Technology Graduate University
Deutsche Forschungsgemeinschaft
National Natural Science Foundation of China
Cited by
3 articles.
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