Human Motor System‐Based Biohybrid Robot‐On‐a‐Chip for Drug Evaluation of Neurodegenerative Disease

Author:

Shin Minkyu1,Ha Taehyeong1,Lim Joungpyo1,An Joohyun1,Beak Geunyoung1,Choi Jin‐Ha2,Melvin Ambrose Ashwin1,Yoon Jinho34,Choi Jeong‐Woo1ORCID

Affiliation:

1. Department of Chemical & Biomolecular Engineering Sogang University 35 Baekbeom‐ro, Mapo‐gu Seoul 04107 Republic of Korea

2. School of Chemical Engineering Jeonbuk National University 567 Baekje‐daero, Deokjin‐gu Jeonju‐si Jeollabuk‐do 54896 Republic of Korea

3. Department of Biomedical‐Chemical Engineering The Catholic University of Korea 43 Jibong‐ro, Wonmi‐gu Bucheon‐si Gyeonggi‐do 14662 Republic of Korea

4. Department of Biotechnology The Catholic University of Korea 43 Jibong‐ro, Wonmi‐gu Bucheon‐si Gyeonggi‐do 14662 Republic ofKorea

Abstract

AbstractBiohybrid robots have been developed for biomedical applications and industrial robotics. However, the biohybrid robots have limitations to be applied in neurodegenerative disease research due to the absence of a central nervous system. In addition, the organoids‐on‐a‐chip has not yet been able to replicate the physiological function of muscle movement in the human motor system, which is essential for evaluating the accuracy of the drugs used for treating neurodegenerative diseases. Here, a human motor system‐based biohybrid robot‐on‐a‐chip composed of a brain organoid, multi‐motor neuron spheroids, and muscle bundle on solid substrateis proposed to evaluate the drug effect on neurodegenerative diseases for the first time. The electrophysiological signals from the cerebral organoid induced the muscle bundle movement through motor neuron spheroids. To evaluate the drug effect on Parkinson's disease (PD), a patient‐derived midbrain organoid is generated and incorporated into a biohybrid robot‐on‐a‐chip. The drug effect on PD is successfully evaluated by measuring muscle bundle movement. The muscle bundle movement of PD patient‐derived midbrain organoid‐based biohybrid robot‐on‐a‐chip is increased from 4.5 ± 0.99 µm to 18.67 ± 2.25 µm in response to levodopa. The proposed human motor system‐based biohybrid robot‐on‐a‐chip can serve as a standard biohybrid robot model for drug evaluation.

Funder

National Research Foundation of Korea

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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