Affiliation:
1. Department of Orthopedics The Second Hospital of Jilin University 4026 Yatai Street Changchun 130041 P. R. China
2. Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences 5625 Renmin Street Changchun 130022 P. R. China
3. Department of Biobank Division of Clinical Research The First Hospital of Jilin University 1 Xinmin Street Changchun 130061 P. R. China
4. Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education The First Hospital of Jilin University 1 Xinmin Street Changchun 130061 P. R. China
Abstract
AbstractRheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of the joints and bone destruction. Because of systemic administration and poor targeting, traditional anti‐rheumatic drugs have unsatisfactory treatment efficacy and strong side effects, including myelosuppression, liver or kidney function damage, and malignant tumors. Consequently, mesenchymal stem cells (MSCs)‐involved therapy is proposed for RA therapy as a benefit of their immunosuppressive and tissue‐repairing effects. This review summarizes the progress of MSCs‐involved RA therapy through suppressing inflammation and promoting tissue regeneration and predicts their potential clinical application.
Funder
Youth Innovation Promotion Association of the Chinese Academy of Sciences
Department of Finance of Jilin Province
Jilin Provincial Scientific and Technological Development Program
Natural Science Foundation of Hebei Province
Innovative Research Group Project of the National Natural Science Foundation of China
Key Technologies Research and Development Program
Cited by
3 articles.
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