Affiliation:
1. National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University Nanjing 210023 P. R. China
2. School of Chemistry and Molecular Engineering Nanjing Tech University Nanjing 211816 P. R. China
3. Key Laboratory of Cardiovascular and Cerebrovascular Medicine School of Pharmacy Nanjing Medical University Nanjing 211166 P. R. China
4. Jiangsu Engineering Research Center of Interfacial Chemistry Nanjing University Nanjing 210023 P. R. China
Abstract
AbstractWith the threat posed by drug‐resistant pathogenic bacteria, developing non‐antibiotic strategies for eradicating clinically prevalent superbugs remains challenging. Ferroptosis is a newly discovered form of regulated cell death that can overcome drug resistance. Emerging evidence shows the potential of triggering ferroptosis‐like for antibacterial therapy, but the direct delivery of iron species is inefficient and may cause detrimental effects. Herein, an effective strategy to induce bacterial nonferrous ferroptosis‐like by coordinating single‐atom metal sites (e.g., Ir and Ru) into the sp2‐carbon‐linked covalent organic framework (sp2c‐COF‐Ir‐ppy2and sp2c‐COF‐Ru‐bpy2) is reported. Upon activating by light irradiation or hydrogen peroxide, the as‐constructed Ir and Ru single‐atom catalysts (SACs) can significantly expedite intracellular reactive oxygen species burst, enhance glutathione depletion‐related glutathione peroxidase 4 deactivation, and disturb the nitrogen and respiratory metabolisms, leading to lipid peroxidation‐driven ferroptotic damage. Both SAC inducers show potent antibacterial activity against Gram‐positive bacteria, Gram‐negative bacteria, clinically isolated methicillin‐resistantStaphylococcus aureus(MRSA), and biofilms, as well as excellent biocompatibility and strong therapeutic and preventive potential in MRSA‐infected wounds and abscesses. This delicate nonferrous ferroptosis‐like strategy may open up new insights into the therapy of drug‐resistant pathogen infection.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)
Cited by
17 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献