Affiliation:
1. Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310006 P. R. China
2. Zhejiang Provincial Key Laboratory of Pancreatic Disease Hangzhou 310003 P. R. China
3. Innovation Center for the Study of Pancreatic Diseases Hangzhou 310003 P. R. China
4. Zhejiang Provincial Clinical Research Center for the Study of Hepatobiliary & Pancreatic Diseases Hangzhou 310003 P. R. China
5. Cancer Center Zhejiang University Hangzhou 310058 P. R. China
Abstract
AbstractPancreatic ductal adenocarcinoma rapidly acquires resistance to chemotherapy, remaining a fatal disease. Immunotherapy is one of the breakthroughs in cancer treatment, which includes immune checkpoint inhibitors, chimeric antigen receptor T‐cell immunotherapy, and neoantigen vaccines. However, immunotherapy has not achieved satisfactory results in the treatment of pancreatic cancer. Immunogenic death comprises proinflammatory cell death, which provides a way to enhance tumor immunogenicity and promote an immune response in solid tumors. Herein, an ionic liquid ablation agent (LAA), synthesized from choline and geranic acid, which triggers necrosis‐induced immunotherapy by remodeling an immunosuppressive “cold” tumor to an immune activated “hot” tumor is described. The results indicate that LAA‐treated tumor cells can enhance immunogenicity, inducing dendritic cell maturation, macrophage M1 polarization, and cytotoxic T lymphocyte infiltration. The results of the present study provide a novel strategy for solid tumor immunotherapy.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
Natural Science Foundation of Zhejiang Province
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)
Cited by
3 articles.
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