Affiliation:
1. Department of Laboratory Medicine The Third Xiangya Hospital Central South University No.138,Tongzipo Road,Yuelu District Changsha Hunan 410013 China
2. Department of Blood Transfusion The Third Xiangya Hospital Central South University No.138,Tongzipo Road,Yuelu District Changsha Hunan 410013 China
3. Hunan Engineering Technology Research Center of Optoelectronic Health Detection Changsha Hunan 410000 China
Abstract
AbstractAlzheimer's disease (AD) is one of the most common neurodegenerative diseases in the elderly population. Despite significant advances in studies of the pathobiology on AD, there is still no effective treatment. Here, an erythrocyte membrane‐camouflaged nanodrug delivery system (TR‐ZRA) modified with transferrin receptor aptamers that can be targeted across the blood–brain barrier to ameliorate AD immune environment is established. Based on metal‐organic framework (Zn‐CA), TR‐ZRA is loaded with CD22shRNA plasmid to silence the abnormally high expression molecule CD22 in aging microglia. Most importantly, TR‐ZRA can enhance the ability of microglia to phagocytose Aβ and alleviate complement activation, which can promote neuronal activity and decrease inflammation level in the AD brain. Moreover, TR‐ZRA is also loaded with Aβ aptamers, which allow rapid and low‐cost monitoring of Aβ plaques in vitro. After treatment with TR‐ZRA, learning, and memory abilities are enhanced in AD mice. In conclusion, the biomimetic delivery nanosystem TR‐ZRA in this study provides a promising strategy and novel immune targets for AD therapy.
Funder
National Natural Science Foundation of China
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)
Cited by
13 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献