Affiliation:
1. Department of Chemical and Biochemical Engineering, University of Western Ontario, London, ON N6A 5B9, Canada
Abstract
The blood–brain barrier (BBB) plays a vital role in safeguarding the central nervous system by selectively controlling the movement of substances between the bloodstream and the brain, presenting a substantial obstacle for the administration of therapeutic agents to the brain. Recent breakthroughs in nanoparticle-based delivery systems, particularly metal–organic frameworks (MOFs), provide promising solutions for addressing the BBB. MOFs have become valuable tools in delivering medications to the brain with their ability to efficiently load drugs, release them over time, and modify their surface properties. This review focuses on the recent advancements in molecular-based approaches for treating brain disorders, such as glioblastoma multiforme, stroke, Parkinson’s disease, and Alzheimer’s disease. This paper highlights the significant impact of MOFs in overcoming the shortcomings of conventional brain drug delivery techniques and provides valuable insights for future research in the field of neurotherapeutics.
Reference78 articles.
1. Lipid nanoparticle-mediated drug delivery to the brain;Khare;Adv. Drug Deliv. Rev.,2023
2. Micro/nanosystems for controllable drug delivery to the brain;Tian;Innovation,2024
3. Estimating the true global burden of mental illness;Vigo;Lancet Psychiatr.,2016
4. Magnetic iron oxide nanoparticles for brain imaging and drug delivery;Qiao;Adv. Drug Deliv. Rev.,2023
5. Liposomes as targetable drug carriers;Torchilin;Crit. Rev. Ther. Drug Carr. Syst.,1985