Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase‐1 Inhibitors by Automated De Novo Design-Reference-Cited by-同舟云学术

Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase‐1 Inhibitors by Automated De Novo Design

Published:2021-06-27 Issue:16 Volume:8 Page:2100832
ISSN:2198-3844
Container-title:Advanced Science
language:en
Short-container-title:Adv. Sci.

Author:

Friedrich Lukas¹,Cingolani Gino²,Ko Ying‐Hui²,Iaselli Mariaclara³,Miciaccia Morena³,Perrone Maria Grazia³,Neukirch Konstantin⁴,Bobinger Veronika¹,Merk Daniel¹⁵,Hofstetter Robert Klaus⁶,Werz Oliver⁶,Koeberle Andreas⁴,Scilimati Antonio³,Schneider Gisbert¹⁷^ORCID

Affiliation:

1. Department of Chemistry and Applied Biosciences ETH Zurich Vladimir‐Prelog‐Weg 4 Zurich 8093 Switzerland

2. Department of Biochemistry and Molecular Biology Sidney Kimmel Cancer Center Thomas Jefferson University 1020 Locust Street Philadelphia PA 19107 USA

3. Department of Pharmacy – Pharmaceutical Sciences University of Bari Via E. Orabona 4 Bari 70125 Italy

4. Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI) University of Innsbruck Innsbruck 6020 Austria

5. Institute of Pharmaceutical Chemistry Goethe‐University Max‐von‐Laue Straße 9 Frankfurt am Main 60438 Germany

6. Department of Pharmaceutical/Medicinal Chemistry Friedrich‐Schiller‐University Jena Philosophenweg 14 Jena 07743 Germany

7. ETH Singapore SEC Ltd 1 CREATE Way, #06‐01 CREATE Tower Singapore 138602 Singapore

Funder

National Institutes of Health

Deutsche Forschungsgemeinschaft

National Cancer Institute

Eidgenössische Technische Hochschule Zürich

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202100832

Reference70 articles.

1. An analysis of FDA-approved drugs: natural products and their derivatives

2. Principle and design of pseudo-natural products

3. Counting on natural products for drug design

4. The Marinopyrroles, Antibiotics of an Unprecedented Structure Class from a Marine Streptomyces sp.

5. Pharmacological Properties of the Marine Natural Product Marinopyrrole A against Methicillin-Resistant Staphylococcus aureus

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