A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference50 articles.
1. Three-dimensional structure of human cyclooxygenase (hCOX)-1;Miciaccia;Sci. Rep.,2021
2. Crystal structure of aspirin-acetylated human cyclooxygenase-2: insight into the formation of products with reversed stereochemistry;Lucido;Biochemistry,2016
3. Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6);Cingolani;Eur. J. Med. Chem.,2017
4. The structural basis of endocannabinoid oxygenation by cyclooxygenase-2;Vecchio;J. Biol. Chem.,2011
5. Learning from nature: from a marine natural product to synthetic cyclooxygenase-1 inhibitors by automated de novo design;Friedrich;Adv. Sci.,2021
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