Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications for Infection and Outcome from SARS‐CoV‐2

Author:

Zhu Hua1,Zhang Hanwen23ORCID,Zhou Nina1,Ding Jin1,Jiang Jinquan1,Liu Teli1,Liu Ziyu14,Wang Feng1,Zhang Qian1,Zhang Zhuochen5,Yan Shi6,Li Lei7,Benabdallah Nadia23,Jin Hongjun8,Liu Zhaofei9,Cai Lisheng10,Thorek Daniel L. J.2311,Yang Xing5,Yang Zhi1

Affiliation:

1. Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research Evaluation of Radiopharmaceuticals (Ministry of Education/Beijing) Department of Nuclear Medicine Peking University Cancer Hospital and Institute Beijing 100142 China

2. Department of Radiology Washington University in St. Louis School of Medicine St. Louis MO 63110 USA

3. Program in Quantitative Molecular Therapeutics Washington University in St. Louis School of Medicine St. Louis MO 63110 USA

4. Department of Nuclear Medicine The Affiliated Hospital of Inner Mongolia Medical University Hohhot 010050 China

5. Department of Nuclear Medicine Peking University First Hospital Beijing 100034 China

6. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Thoracic Surgery II Peking University Cancer Hospital and Institute Beijing 100142 China

7. Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Scientific Key Lab Beijing 100730 China

8. Guangdong Provincial Key Laboratory of Biomedical Imaging Fifth Affiliated Hospital Sun Yat‐sen University Zhuhai Guangdong Province 519000 China

9. Medical Isotopes Research Center and Department of Radiation Medicine School of Basic Medical Sciences Peking University Health Science Center Beijing 100191 China

10. Molecular Imaging Branch National Institute of Mental Health National Institutes of Health Bethesda MD 20892 USA

11. Department of Biomedical Engineering Washington University in St. Louis St. Louis MO 63110 USA

Funder

National Science and Technology Major Project

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Reference63 articles.

1. Angiotensin‐converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection

2. World Health Organization Coronavirus Disease 2019 (COVID‐19): Situation Report https://www.who.int/emergencies/diseases/novel‐coronavirus‐2019/situation‐reports2020(accessed: March 2021).

3. COVID‐19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University https://coronavirus.jhu.edu/map.html2020(accessed: March 2021).

4. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

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