Preclinical Evaluation and Pilot Clinical Study of 18F-Labeled Inhibitor Peptide for Noninvasive Positron Emission Tomography Mapping of Angiotensin Converting Enzyme 2

Author:

Ding Jin1,Zhang Qian12,Jiang Jinquan3,Zhou Nina1,Yu Ziyu4,Wang Zilei1,Meng Xiangxi1ORCID,Daggumati Lasya5,Liu Teli1,Wang Feng1,Lu Zhihao6,Yang Xing7ORCID,Yang Zhi1ORCID,Zhang Hanwen5,Thorek Daniel L. J.5ORCID,Du Peng4,Zhu Hua1ORCID

Affiliation:

1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, Beijing 100142, China

2. Guizhou University School of Medicine, Guiyang, 550025 Guizhou, China

3. Department of Radiology, People’s Hospital of Deyang City, Deyang, 618000 Sichuan, China

4. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Urology, Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, 100142 Beijing, China

5. Department of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri 63110, United States

6. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastro-intestinal oncology, Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, 100142 Beijing, China

7. Department of Nuclear Medicine, Peking University First Hospital, No. 8 Xishiku Street, 100034 Beijing, China

Funder

National Natural Science Foundation of China

Beijing Municipal Medical Research Institute

Beijing Hospitals Authority Dengfeng Project

Youth Talent Support Program

Science Foundation of Peking University Cancer Hospital

Publisher

American Chemical Society (ACS)

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1. Radiotracers for Molecular Imaging of Angiotensin-Converting Enzyme 2;International Journal of Molecular Sciences;2024-08-30

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