Inhibition of Calcium Signaling Prevents Exhaustion and Enhances Anti‐Leukemia Efficacy of CAR‐T Cells via SOCE‐Calcineurin‐NFAT and Glycolysis Pathways-Reference-Cited by-同舟云学术

Inhibition of Calcium Signaling Prevents Exhaustion and Enhances Anti‐Leukemia Efficacy of CAR‐T Cells via SOCE‐Calcineurin‐NFAT and Glycolysis Pathways

Published:2022-01-14 Issue:9 Volume:9 Page:2103508
ISSN:2198-3844
Container-title:Advanced Science
language:en
Short-container-title:Advanced Science

Author:

Shao Mi¹²³⁴,Teng Xinyi¹²³⁴,Guo Xin¹²³⁴,Zhang Hao⁵,Huang Yue¹²³⁴,Cui Jiazhen¹²³⁴,Si Xiaohui¹²³⁴,Ding Lijuan¹²³⁴,Wang Xiujian¹²³⁴,Li Xia¹²³⁴,Shi Jimin¹²³⁴,Zhang Mingming¹²³⁴,Kong Delin¹²³⁴,Gu Tianning¹²³⁴,Hu Yongxian¹²³⁴^ORCID,Qian Pengxu²³⁴⁶^ORCID,Huang He¹²³⁴^ORCID

Affiliation:

1. Bone Marrow Transplantation Center The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310003 China

2. Institute of Hematology Zhejiang University Hangzhou Zhejiang 310030 China

3. Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy Hangzhou Zhejiang 310030 China

4. Liangzhu Laboratory Zhejiang University Medical Center Hangzhou Zhejiang 311121 China

5. Department of Hematology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang 315200 China

6. Center of Stem Cell and Regenerative Medicine Zhejiang University School of Medicine Hangzhou Zhejiang 310030 China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202103508

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2. Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

3. Intent-to-treat leukemia remission by CD19 CAR T cells of defined formulation and dose in children and young adults

4. CD19-targeted CAR T-cell therapeutics for hematologic malignancies: interpreting clinical outcomes to date

5. Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

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