Odanacatib Pharmacokinetics Comparison Between Chinese and Non-Chinese Postmenopausal Women

Author:

Chen Xia12,Jiang Ji12,Hu Pei12,Zajic Stefan3,Liu Wen3,McCrea Jacqueline3,Liu Fang3,Witter Rose3,Mangin Eric3,Stoch S. Aubrey3

Affiliation:

1. Peking Union Medical College Hospital; Clinical Pharmacological Research Center; Beijing China

2. Beijing Key Laboratory of Clinical PK and PD Investigation for Innovative Drugs; Beijing China

3. Merck & Co., Inc.    ; Kenilworth NJ USA

Funder

Merck

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Reference16 articles.

1. Odanacatib, a cathepsin-K inhibitor for osteoporosis: a two-year study in postmenopausal women with low bone density;Bone;J Bone Miner Res.,2010

2. Odanacatib in the treatment of postmenopausal women with low bone mineral density: three-year continued therapy and resolution of effect;Eisman;J Bone Miner Res,2011

3. Odanacatib in the treatment of postmenopausal women with low bone mineral density: five years of continued therapy in a phase 2 study;Langdahl;J Bone Miner Res,2012

4. Effect of the cathepsin K inhibitor odanacatib administered once weekly on bone mineral density in Japanese patients with osteoporosis-a double-blind, randomized, dose-finding study;Nakamura;Osteoporos Int,2014

5. Merck &Co. drops osteoporosis drug odanacatib;Mullard;Nat Rev Drug Discov.,2016

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