Photoredox C sp 3 −C sp 2 Reductive Cross‐Couplings of Cereblon Ligands for PROTAC Linker Exploration in Batch and Flow-Reference-Cited by-同舟云学术

Photoredox C _sp ³ −C _sp ² Reductive Cross‐Couplings of Cereblon Ligands for PROTAC Linker Exploration in Batch and Flow

Published:2022-11-11 Issue:24 Volume:14 Page:
ISSN:1867-3880
Container-title:ChemCatChem
language:en
Short-container-title:ChemCatChem

Author:

Steiner Alexander¹²^ORCID,Krieger Johannes³^ORCID,Jones Reinaldo⁴,Böse Dietrich³^ORCID,Wang Yanping⁴,Eggenweiler Hans‐Michael³^ORCID,Williams Jason D.¹²^ORCID,Kappe C. Oliver¹²^ORCID

Affiliation:

1. Center for Continuous Flow Synthesis and Processing (CCFLOW) Research Center Pharmaceutical Engineering GmbH (RCPE) Inffeldgasse 13 8010 Graz Austria

2. Institute of Chemistry University of Graz NAWI Graz Heinrichstrasse 28 8010 Graz Austria

3. Global Medicinal Chemistry Merck Healthcare KGaA Frankfurter Str. 250 64293 Darmstadt Germany

4. Global Medicinal Chemistry Healthcare R&D EMD Serono 45 A Middlesex Turnpike 01821 Billerica MA USA

Funder

Österreichische Forschungsförderungsgesellschaft

Publisher

Wiley

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cctc.202201184

Reference69 articles.

1. Targeted protein degraders crowd into the clinic

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4. Recent Developments in PROTAC‐Mediated Protein Degradation: From Bench to Clinic

5. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

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