Affiliation:
1. Department of Pharmacy Faculty of Pharmaceutical Sciences Hokkaido University of Science 006-8585 Sapporo Japan
2. Department of Chemistry Graduate School of Science Hokkaido University 060-0810 Sapporo Japan
Abstract
AbstractDevelopment of the efficient and practical method for the synthesis of deuterated compounds which occupies the broadest area among stable isotopes is one of the most essential issues toward the industrial advance and building a sustainable society. This review describes recent advances in deuteration reactions, where the continuous flow chemistry plays pivotal roles for the successful installation of deuterium atom into diverse organic frameworks, opening new fields of isotope‐based synthetic chemistry.