Efforts toward the first total synthesis of a mixed‐ligand siderophore: Gobichelin‐A
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Published:2023-05-25
Issue:12
Volume:29
Page:
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ISSN:1075-2617
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Container-title:Journal of Peptide Science
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language:en
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Short-container-title:Journal of Peptide Science
Author:
Shankar Bhookya1,
Venkatesh Bhumireddy Chinnachennaiahgari1,
Sridhar Perali Ramu1ORCID
Affiliation:
1. School of Chemistry University of Hyderabad Hyderabad India
Abstract
The synthesis of Gobichelin‐A, a naturally occurring mixed‐ligand siderophore isolated from Streptomyces sp. NRRL F‐4415, is described. The target molecule was planned to be synthesized by a convergent process involving the combination of two halves, Gob‐A 1st half and Gob‐A 2nd half, at the prefinal stage of the synthetic route. By adopting this method, fully protected Gobichelin‐A was synthesized in excellent yield.
Funder
Department of Biotechnology, Ministry of Science and Technology, India
University Grants Commission
Subject
Organic Chemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry,Structural Biology