Model-Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities

Author:

Keizer Ron J.1,ter Heine Rob2,Frymoyer Adam3,Lesko Lawrence J.4,Mangat Ranvir1,Goswami Srijib1

Affiliation:

1. InsightRX; San Francisco California USA

2. Department of Pharmacy & Radboud Applied Pharmacometrics Group; Radboudumc; Nijmegen The Netherlands

3. Department of Pediatrics; Stanford University; Stanford California USA

4. Center for Pharmacometrics and Systems Pharmacology; University of Florida; Orlando Florida USA

Publisher

Wiley

Subject

Pharmacology (medical),Modelling and Simulation

Reference12 articles.

1. Computer-aided long-term anticoagulation therapy;Sheiner;Comput. Biomed. Res.,1969

2. Why has model-informed precision dosing not yet become common clinical reality? Lessons from the past and a roadmap for the future;Darwich;Clin. Pharmacol. Ther.,2017

3. Precision dosing: public health need, proposed framework, and anticipated impact;Gonzalez;Clin. Transl. Sci.,2017

4. The time is now: model-based dosing to optimize drug therapy;Chan;Int. J. Pharmacokinet.,2017

5. Computerized advice on drug dosage to improve prescribing practice;Gillaizeau;Cochrane Database Syst. Rev.,2013

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