A rapid and sensitive bioanalytical LC–MS/MS method for the quantitation of a novel CDK5 inhibitor 20–223 (CP668863) in plasma: Application to in vitro metabolism and plasma protein‐binding studies-Reference-Cited by-同舟云学术

A rapid and sensitive bioanalytical LC–MS/MS method for the quantitation of a novel CDK5 inhibitor 20–223 (CP668863) in plasma: Application to in vitro metabolism and plasma protein‐binding studies

Published:2020-05-18 Issue:8 Volume:34 Page:
ISSN:0269-3879
Container-title:Biomedical Chromatography
language:en
Short-container-title:Biomedical Chromatography

Author:

Bala Veenu¹²,Chhonker Yashpal S.¹^ORCID,Sleightholm Richard L.³,Crawford Ayrianne J.⁴,Hollingsworth Michael A.⁴⁵,Murry Daryl J.¹⁴

Affiliation:

1. Clinical Pharmacology Laboratory, Department of Pharmacy Practice and ScienceUniversity of Nebraska Medical Center Omaha NE USA

2. Department of Pharmaceutical SciencesMohanlal Sukhadia University Udaipur India

3. Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical SciencesUniversity of Nebraska Medical Center Omaha NE USA

4. Fred and Pamela Buffett Cancer CenterUniversity of Nebraska Medical Center Omaha NE USA

5. Eppley Institute for Research in Cancer and Allied DiseasesUniversity of Nebraska Medical Center Omaha NE USA

Funder

National Cancer Institute

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bmc.4859

Reference26 articles.

1. A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition

2. The history and future of targeting cyclin-dependent kinases in cancer therapy

3. Protein binding of atenolol and propranolol to human serum albumin and in human plasma [proceedings]

4. Metabolite profiling study of propranolol in rat using LC/MS/MS analysis

5. Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer

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