Aldo-Keto Reductase 1C3 Inhibitor Prodrug Improves Pharmacokinetic Profile and Demonstrates In Vivo Efficacy in a Prostate Cancer Xenograft Model-Reference-Cited by-同舟云学术

Aldo-Keto Reductase 1C3 Inhibitor Prodrug Improves Pharmacokinetic Profile and Demonstrates In Vivo Efficacy in a Prostate Cancer Xenograft Model

Published:2023-07-10 Issue:14 Volume:66 Page:9894-9915
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Maddeboina Krishnaiah¹,Jonnalagadda Sravan K.¹,Morsy Ahmed¹,Duan Ling²,Chhonker Yashpal S.³,Murry Daryl J.³⁴,Penning Trevor M.²^ORCID,Trippier Paul C.¹⁴⁵^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68106, United States

2. Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

3. Department of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68106, United States

4. Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68106, United States

5. UNMC Center for Drug Discovery, University of Nebraska Medical Center, Omaha, Nebraska 68106, United States

Funder

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00732

Reference54 articles.

1. Prostate cancer epidemiology in the United States

2. Androgen deprivation therapy for prostate cancer: Current status and future prospects

3. Characterising the castration-resistant prostate cancer population: a systematic review

4. Androgen receptor splice variants and prostate cancer: From bench to bedside

5. Androgen Levels Increase by IntratumoralDe novoSteroidogenesis during Progression of Castration-Resistant Prostate Cancer

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