Affiliation:
1. Nottingham Breast Institute, City Hospital, Nottingham NG1 5PB, UK
Abstract
Abstract
Background
Accurate localization of impalpable breast lesions that require biopsy is important. This randomized trial compared radioisotope occult lesion localization (ROLL) with the standard hooked-wire technique.
Methods
Ninety-five patients were randomized to receive either ROLL or wire localization of an occult breast lesion. Correct placement of isotope was confirmed by mammography and a hand-held γ probe was used to guide the surgical excision. Radiological, surgical and pathological data were compared for accuracy, duration and ease of technique, and histopathological diagnosis. Procedure-related pain was also assessed.
Results
Of the 95 patients entered, 48 were randomized to ROLL and 47 to wire localization. Two ROLL procedures failed. Marking was accurate in 46 of 48 ROLL procedures and 44 of 47 of wire localizations (P = 0·242). Difficulty in localization (Likert score 2·6 for ROLL versus 4·4 for wire localization; P < 0·001) and the degree of surgical difficulty (2·6 versus 4·0; P < 0·001) were significantly less for ROLL. ROLL was associated with less pain (score 2·7 versus 3·6; P = 0·012). There were no significant differences in mean duration of operation, specimen weight, need for intraoperative re-excision or second therapeutic operation.
Conclusion
ROLL and wire-guided localization were similarly effective for breast biopsy, but ROLL was easier for both radiologist and surgeon, and less painful for the patient.
Publisher
Oxford University Press (OUP)
Cited by
125 articles.
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