3D simulation of nano/micro cellulose delivery systems for dermic and respiratory applications: Case study of eucalyptus essential oil incorporation

Abstract

AbstractThe purpose of this work was to design, develop and optimize different combinations of drug delivery systems (DDS) with nanofibrillated (NFC) and microfibrillated (MFC) cellulose‐based materials, as 3D networks, encapsulating eucalyptus essential oil molecules, for dermic and respiratory applications. Experimental and computational approaches were implemented for characterization, modeling studies, and structure porosity optimization. The optimized porous structures were able to retain the desired molecules, resulting in more controlled and uniform release kinetics over time. This methodology allowed for optimizing new bio‐based drug delivery systems with controlled porosity, pore dimension and distribution, retention of therapeutic molecules, and uniformity of the 3D network. The results showed that different drug delivery systems with this 3D matrix released the essential oil molecules, improving its stability and prolonging the exposure time, factors that are important to develop promising drug delivery systems in biomaterials fields. Overall, cellulose‐based structured biomaterials capable of transporting and releasing essential oil components are representatives of innovative materials that will be used in novel applications, in which the exposure time to the therapeutic molecules constitutes a competitive benefit.