Affiliation:
1. Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research Jamia Hamdard New Delhi India
Abstract
AbstractOxadiazoles and thiadiazoles are malleable heterocycles that have recently generated major interest in the field of medicinal chemistry. Compounds based on these moieties have versatile biological applications such as anticonvulsant, anticancer, antidiabetic, and antioxidant agents. Due to the versatile nature and stability of the oxadiazole and thiadiazole nucleus, medicinal chemists have changed the structural elements of the ring in numerous ways. These compounds have shown significant anticonvulsant effects, demonstrating their potential in the management of epileptic disorders. In this review, we have covered numerous biological pathways and in silico targeted proteins of oxadiazole and thiadiazole derivatives for treating various biological disorders. The data compiled in this article will be helpful for researchers, research scientists, and research chemists who work in the field of drug discovery and drug development.
Funder
University Grants Commission
All India Council for Technical Education
Hamdard National Foundation
Subject
Drug Discovery,Pharmaceutical Science