Synthesis, Properties, and Biological Applications of 1,3,4-Thiadiazoles

Abstract

1,3,4-Thiadiazoles are ubiquitous heterocyclic compounds found to have a wide range of applications in the fields of materials science, agriculture, and medicinal chemistry. They have garnered significant interest among researchers due to their vast therapeutic potential. Consequently, they have emerged as captivating chemical building blocks for developing innovative bioactive chemicals. The chemical modifications of the thiadiazole ring lead to an improvement in its pharmacokinetic and pharmacological profiles. The present scaffold has already proven effective in various clinical settings. In this chapter, we delve deeper into conventional and green synthetic methods for the preparation of substituted 1,3,4-thiadiazoles. Moreover, a comprehensive analysis has been conducted to examine the numerous biological activities associated with this particular scaffold.