Pharmacophore‐linked pyrazolo[3,4‐ d ]pyrimidines as EGFR‐TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies-Reference-Cited by-同舟云学术

Pharmacophore‐linked pyrazolo[3,4‐ d ]pyrimidines as EGFR‐TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies

Published:2021-08-31 Issue: Volume: Page:
ISSN:0365-6233
Container-title:Archiv der Pharmazie
language:en
Short-container-title:Arch Pharm

Author:

Gaber Ahmed A.¹,El‐Morsy Ahmed M.¹²^ORCID,Sherbiny Farag F.¹³,Bayoumi Ashraf H.¹^ORCID,El‐Gamal Kamal M.¹^ORCID,El‐Adl Khaled⁴⁵^ORCID,Al‐Karmalawy Ahmed A.⁶^ORCID,Ezz Eldin Rogy R.⁷^ORCID,Saleh Marwa A.⁸^ORCID,Abulkhair Hamada S.¹⁶^ORCID

Affiliation:

1. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy Al‐Azhar University Cairo Nasr City Egypt

2. Pharmaceutical Chemistry Department, College of Pharmacy The Islamic University Najaf Iraq

3. Department of Chemistry, Basic Science Center and Pharmaceutical Organic Chemistry College of Pharmaceutical Science & Drug Manufacturing Misr University for Science and Technology (MUST) Al‐Motamayez District 6th of October City Egypt

4. Department of Medicinal Chemistry & Drug Design, Faculty of Pharmacy Al‐Azhar University Cairo Nasr City Egypt

5. Department of Pharmaceutical Chemistry, Faculty of Pharmacy Heliopolis University for Sustainable Development Cairo Egypt

6. Pharmaceutical Chemistry Department, Faculty of Pharmacy Horus University–Egypt New Damietta Egypt

7. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy Port Said University Port Said Egypt

8. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls) Al‐Azhar University Cairo Egypt

Publisher

Wiley

Subject

Drug Discovery,Pharmaceutical Science

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ardp.202100258

Reference67 articles.

1. Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment

2. Imaging of EGFR and EGFR Tyrosine Kinase Overexpression in Tumors by Nuclear Medicine Modalities

3. Synthesis of 4,6-disubstituted pyrazolo[3,4-d]pyrimidine analogues: Cyclin-dependent kinase 2 (CDK2) inhibition, molecular docking and anticancer evaluation

4. Antitumor evaluation and molecular docking study of substituted 2-benzylidenebutane-1,3-dione, 2-hydrazonobutane-1,3-dione and trifluoromethyl-1H-pyrazole analogues

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