Affiliation:
1. State Key Laboratory of Targeting Oncology, National Center for International Research of Bio‐targeting Theranostics, Guangxi Key Laboratory of Bio‐targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio‐targeting Theranostics Guangxi Medical University Nanning China
2. Pharmaceutical College Guangxi Medical University Nanning China
3. The First People's Hospital of Changde City Changde China
Abstract
AbstractThe discovery of new therapeutic drugs is heavily reliant on the structural diversity and pharmacological properties of heterocyclic compounds. Pyridine heterocyclic‐related medicines, in particular, have garnered considerable attention due to their wide pharmacological activities and therapeutic effects. Among them, cyanopyridine derivatives have demonstrated diverse pharmacological effects. This review aims to systematically compile and discuss the diverse pharmacological effects of cyanopyridine derivatives. The review is divided into multiple sections, highlighting the biological activities of cyanide derivatives, with emphasis on anticancer, antimicrobial (i.e., antibacterial, insecticidal anticonvulsant, and antiviral activities), anticonvulsant, anti‐Alzheimer's, and enzyme inhibitory activities. Furthermore, the review emphasizes the interesting therapeutic potential of cyanopyridine derivatives as kinase inhibitors and cytotoxic agents, which are promising candidates for anticancer drug development. The relationship between structure and activity is also discussed, with molecular docking used to provide insights into the mechanism of action of these compounds.
Subject
Drug Discovery,Pharmaceutical Science
Cited by
6 articles.
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