Affiliation:
1. Department of Chemistry Tamkang University Tamsui District New Taipei City Taiwan
2. Research Center for Chinese Herbal Medicine, Graduate Institute of Healthy Industry Technology, College of Human Ecology Chang Gung University of Science and Technology Taoyuan Taiwan
3. Department of Nutrition and Health Science, College of Human Ecology Chang Gung University of Science and Technology Taoyuan Taiwan
Abstract
AbstractPreviously, we documented the synthesis and assessed the biological effects of chalcones containing selenium against HT‐29 human colorectal adenocarcinoma cells, demonstrating their significant potential. As research on selenium‐containing flavonoids remains limited, this article outlines our design and synthesis of three selenium‐based flavonols and three 2‐styrylchromones. We conducted evaluations of these compounds to determine their impact on human lung cancer cells (A549, H1975, CL1‐0, and CL1‐5) and their influence on normal lung fibroblast MRC5 cells. Additionally, we included selenium‐based chalcones in our testing for comparative purposes. Our findings highlight that the simplest compound, designated as compound 1, exhibited the most promising performance among the tested molecules.