Affiliation:
1. Department of Biomolecular Systems Max-Planck-Institute of Colloids and Interfaces Am Mühlenberg 1 14476 Potsdam Germany
2. Institute of Science and Technology Austria (ISTA) Am Campus 1 3400 Klosterneuburg Austria
Abstract
AbstractWe present a photon‐ and metal‐free approach for the radical fluorination of aliphatic oxalate‐activated alcohols. The method relies on the spontaneous generation of the N‐(chloromethyl)triethylenediamine radical dication, a potent single electron oxidant, from Selectfluor and 4‐(dimethylamino)pyridine. The protocol is easily scalable and provides the desired fluorinated products within only a few minutes reaction time.
Funder
Boehringer Ingelheim Stiftung
Subject
Organic Chemistry,Physical and Theoretical Chemistry