Selective Synthesis of Cyclic Nitroene‐Sulfonamides from Aliphatic Sulfamides and NOBF4

Abstract

AbstractDescribed herein is the development of a desaturation and N‐β‐nitration reaction of cyclic amides, which is achieved by a selective hydrogen atom transfer (HAT)/oxidative desaturation/electrophilic nitration process. In this procedure, di‐tert‐butyl peroxide (DTBP) acted both as the oxidant and HAT reagent, and electrophilic NOBF4 as nitration source. Notably, the application of produced cyclic nitroene‐sulfonamides was showcased by their efficient transformations into 3‐piperidones and poly‐substituted piperidine derivatives.