Cobalt‐Catalyzed, 2‐Aminopyridine‐N‐Oxide‐Directed C(sp2)−H Bond Functionalization with Maleimides: Facile Access to Isoindolone Spirosuccinimides

Abstract

AbstractA cobalt‐catalyzed, N,O‐bidentate directing group‐assisted C−H bond functionalization of benzamides with maleimides was developed for the facile access to isoindolone spirosuccinimides in good to excellent yields. This C−H bond activation and spirocyclization employing pyridine N‐oxide as directing group provided very good substrate scope and tolerated various functional groups. Furthermore, the mechanistic investigation revealed that the C−H bond activation is the rate‐determining step of this reaction.