Affiliation:
1. Engineering Research Centre of Molecular Medicine of Ministry of Education Key Laboratory of Fujian Molecular Medicine Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences Huaqiao University Xiamen 361021 P. R. China
2. School of Biomedical Sciences Huaqiao University Quanzhou 362021 P. R. China
Abstract
AbstractA highly efficient strategy to construct benzo[d][1,3]diazepines via selective C−H bond activation of N‐aryl amidines and coupling with alkynyl cyclobutyl acetates was achieved successfully by RuII‐catalyzed [5+2] cyclization. This protocol features excellent regioselectivity, wide substrate tolerance, mild reaction conditions, which might be potentially applied in the discovery of lead compounds for the developing new drugs.
Funder
Higher Education Discipline Innovation Project
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Cited by
3 articles.
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