Synthesis of (−)‐( R )‐Sitagliptin by Rh I ‐Catalyzed Asymmetric Hydroamination

Author:

Berthold Dino1,Breit Bernhard1

Affiliation:

1. Institut für Organische Chemie and Freiburg Albert-Ludwigs-Universität Freiburg Albertstraße 21 79104 Freiburg im Breisgau Germany

Publisher

Wiley

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference52 articles.

1. International Diabetes Federation (IDF) Diabetes Atlas 8thed. 2017;http://www.idf.org/diabatesatlas.

2. (2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine:  A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

3. The list of top 200 small molecule pharmaceuticals by retail is compiled and produced by the group of Njardson from the University of Arizona and is accessible using the following link:https://njardarson.lab.arizona.edu/sites/njardarson.lab.arizona.edu/files/Top%20200%20Small%20Molecule%20Pharmaceuticals%202018V4.pdf(Last accessed from website: 28.5.2021).

4. Efficient stereocontrolled synthesis of sitagliptin phosphate

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