Engineering redox sensors into CHO cells enables near‐real‐time quantification of intracellular redox in bioprocesses
Author:
Affiliation:
1. Cell Culture and Fermentation Sciences BioPharmaceuticals Development, R&D, AstraZeneca Gaithersburg Maryland USA
2. Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore Maryland USA
Publisher
Wiley
Subject
Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.28067
Reference32 articles.
1. Multi‐Omics Reveals Impact of Cysteine Feed Concentration and Resulting Redox Imbalance on Cellular Energy Metabolism and Specific Productivity in CHO Cell Bioprocessing
2. Multi‐Omics Study on the Impact of Cysteine Feed Level on Cell Viability and mAb Production in a CHO Bioprocess
3. Mitochondrial membrane potential-enriched CHO host: a novel and powerful tool for improving biomanufacturing capability
4. Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells
5. Characterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis
Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Understanding the effect of temperature downshift onCHOcell growth, antibody titer and product quality by intracellular metabolite profiling and in vivo monitoring of redox state;Biotechnology Progress;2023-05-04
2. Data‐driven prediction models for forecasting multistep ahead profiles of mammalian cell culture toward bioprocess digital twins;Biotechnology and Bioengineering;2023-04-20
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