Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV‐1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine-Reference-Cited by-同舟云学术

Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV‐1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine

Published:2019-08-06 Issue:9 Volume:28 Page:1664-1675
ISSN:0961-8368
Container-title:Protein Science
language:en
Short-container-title:Protein Science

Author:

Bertoletti Nicole¹^ORCID,Chan Albert H.¹,Schinazi Raymond F.²,Yin Y. Whitney³⁴,Anderson Karen S.¹⁵^ORCID

Affiliation:

1. Department of Pharmacology Yale University School of Medicine New Haven Connecticut

2. Laboratory of Biochemical Pharmacology, Department of Pediatrics, Center for AIDS Research Emory University School of Medicine Atlanta Georgia

3. Department of Pharmacology and Toxicology University of Texas Medical Branch Galveston Texas

4. Sealy Center for Structural Biology University of Texas Medical Branch Galveston Texas

5. Department of Molecular Biophysics and Biochemistry Yale University School of Medicine New Haven Connecticut

Funder

National Institute of Allergy and Infectious Diseases

National Institute of General Medical Sciences

Brookhaven National Laboratory

Argonne National Laboratory

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/pro.3681

Reference53 articles.

1. The HIV therapy market

2. Toxicity of Antiretroviral Nucleoside and Nucleotide Analogues

3. Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective

4. Relationship between Antiviral Activity and Host Toxicity: Comparison of the Incorporation Efficiencies of 2′,3′-Dideoxy-5-Fluoro-3′-Thiacytidine-Triphosphate Analogs by Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Human Mitochondrial DNA Polymerase

5. Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ

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