Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd1201.pdf
Reference156 articles.
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2. Dalakas, M. C. et al. Mitochondrial myopathy caused by long-term zidovudine therapy. N. Engl. J. Med. 322, 1098–1105 (1990). The first report of mitochondrial toxicity from NRTIs with ultrastructural similarities to mitochondrial myopathy.
3. Lewis, W. et al. Mitochondrial ultrastructural and molecular changes induced by zidovudine in rat hearts. Lab. Invest. 65, 228–236 (1991).
4. Lewis, W., Gonzalez, B., Chomyn, A. & Papoian, T. Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria. J. Clin. Invest. 89, 1354–1360 (1992). Reports a link between mtDNA depletion, mtRNA depletion, mitochondrial ultrastructural defects and AZT treatment and myopathy.
5. Lewis, W. et al. Fialuridine and its metabolites inhibit DNA polymerase γ at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts. Proc. Natl Acad. Sci. USA 93, 3592–3597 (1996). Establishes competitive inhibition as operative with the pharmacologically active FIAU metabolites.
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