A2T and A2V Aβ peptides exhibit different aggregation kinetics, primary nucleation, morphology, structure, and LTP inhibition-Reference-Cited by-同舟云学术

A2T and A2V Aβ peptides exhibit different aggregation kinetics, primary nucleation, morphology, structure, and LTP inhibition

Published:2016-02-23 Issue:4 Volume:84 Page:488-500
ISSN:0887-3585
Container-title:Proteins: Structure, Function, and Bioinformatics
language:en
Short-container-title:Proteins

Author:

Murray Brian¹,Sorci Mirco¹,Rosenthal Joseph²,Lippens Jennifer³,Isaacson David²,Das Payel⁴,Fabris Daniele³,Li Shaomin⁵,Belfort Georges¹

Affiliation:

1. Department of Chemical and Biological Engineering and Center for Biotechnology and Interdisciplinary Studies; Rensselaer Polytechnic Institute; Troy New York 12180

2. Department of Mathematical Sciences; Rensselaer Polytechnic Institute; Troy New York 12180

3. Department of Chemistry; University at Albany, State University of New York; Albany New York 12222

4. Soft Matter Theory and Simulations Group; Computational Biology Center, IBM Thomas J. Watson Research Center; Yorktown Heights New York 10598

5. Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School; Boston Massachusetts 02115

Funder

National Institutes of Health

Rensselaer Polytechnic Institute

Publisher

Wiley

Subject

Molecular Biology,Biochemistry,Structural Biology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/prot.24995/fullpdf

Reference60 articles.

1. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway;Shankar;J Neurosci Off JSoc Neurosci,2007

2. Oligomeric intermediates in amyloid formation: structure determination and mechanisms of toxicity;Fandrich;J Mol Biol,2012

3. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics;Hardy;Science,2002

4. Twenty years of Alzheimer's disease-causing mutations;Goate;J Neurochem,2012

5. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline;Jonsson;Nature,2012

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