Sucrose prevents protein fibrillation through compaction of the tertiary structure but hardly affects the secondary structure

Author:

Estrela Nídia1,Franquelim Henri G.2,Lopes Carlos1,Tavares Evandro1,Macedo Joana A.1,Christiansen Gunna3,Otzen Daniel E.4,Melo Eduardo P.15

Affiliation:

1. Centre for Biomedical Research (CBMR); University of Algarve, Campus of Gambelas; Faro 8005-139 Portugal

2. Instituto De Medicina Molecular; Faculdade De Medicina Da Universidade De Lisboa; Av. Prof. Egas Moniz, Edifício Egas Moniz Lisboa 1649-028 Portugal

3. Department of Biomedicine; Aarhus University; Aarhus C DK-8000 Denmark

4. Department of Molecular Biology and Genetics; Aarhus University, iNANO (Interdisciplinary Nanoscience Centre); Gustav Wieds Vej 14 Aarhus C 8000 Denmark

5. Instituto Superior Técnico, Centro De Química Estrutural; Av. Rovisco Pais Lisboa 1049-001 Portugal

Funder

Fundação para a Ciência e Tecnologia (FCT), Portugal

FCT through Research Center

Grant sponsor: Programa Nacional de Re-equipamento

Grant sponsor: FCT, Portugal

European program FEDER, European Regional Development Fund through COMPETE

Publisher

Wiley

Subject

Molecular Biology,Biochemistry,Structural Biology

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