In Vitro Assays of Chemotaxis as a Window into Mechanisms of Toxicant‐Induced Immunomodulation
Author:
Affiliation:
1. Department of Molecular and Cell Biology, University of Connecticut Storrs Connecticut
Publisher
Wiley
Subject
Toxicology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/0471140856.tx1817s58
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1. Cholera toxin inhibits chemotaxis by a cAMP-independent mechanism.
2. The inhibition of neutrophil granule enzyme secretion and chemotaxis by pertussis toxin.
3. Selective inhibition of interleukin-8-induced neutrophil chemotaxis by ketoprofen isomers 11Abbreviations: NSAIDs, non-steroidal anti-inflammatorydrugs; COX, cyclooxygenase; PG, prostaglandin; PMN, humanpolymorphonuclear leukocyte; IL-8, interleukin-8;[Ca2+]i, intracellular calcium concentration;MAPK, mitogen-activated protein kinases; fMLP,N-formyl-methionyl-leucyl-phenylalanine; ERK, extracellular signalregulated kinase; C5a, fifth component of complement; MCP-1, monocytechemotactic protein-1; NAP-2, neutrophil activating protein-2; GCP-2,granulocyte chemotactic peptide-2; PVP, polyvinylpyrrolidone; HBSS,Hank’s balanced salt solution; ENA-78, epithelial-derived neutrophilactivating protein-78; ECL, enhanced chemiluminescent; FURA-2AM;1-[2-(5-carboxyoxazol-2-yl)-6-amino-benzofuran-5-oxy]-2-(2′-amino-5′-ethlphenoxy)-ethane-N,N,N′,N′-tetraaceticacid pentaacetoxy methylester; MGSA/GRO, melanoma growth stimulatoryactivity/gene product of gro gene.
4. THE CHEMOTACTIC EFFECT OF MIXTURES OF ANTIBODY AND ANTIGEN ON POLYMORPHONUCLEAR LEUCOCYTES
5. A Single Cell Density-sensing Factor Stimulates Distinct Signal Transduction Pathways through Two Different Receptors
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