Selective inhibition of interleukin-8-induced neutrophil chemotaxis by ketoprofen isomers 11Abbreviations: NSAIDs, non-steroidal anti-inflammatorydrugs; COX, cyclooxygenase; PG, prostaglandin; PMN, humanpolymorphonuclear leukocyte; IL-8, interleukin-8;[Ca2+]i, intracellular calcium concentration;MAPK, mitogen-activated protein kinases; fMLP,N-formyl-methionyl-leucyl-phenylalanine; ERK, extracellular signalregulated kinase; C5a, fifth component of complement; MCP-1, monocytechemotactic protein-1; NAP-2, neutrophil activating protein-2; GCP-2,granulocyte chemotactic peptide-2; PVP, polyvinylpyrrolidone; HBSS,Hank’s balanced salt solution; ENA-78, epithelial-derived neutrophilactivating protein-78; ECL, enhanced chemiluminescent; FURA-2AM;1-[2-(5-carboxyoxazol-2-yl)-6-amino-benzofuran-5-oxy]-2-(2′-amino-5′-ethlphenoxy)-ethane-N,N,N′,N′-tetraaceticacid pentaacetoxy methylester; MGSA/GRO, melanoma growth stimulatoryactivity/gene product of gro gene.