Evaluation of a P,N-ligated iridium(I) catalyst in hydrogen isotope exchange reactions of aryl and heteroaryl compounds
Author:
Affiliation:
1. R&D, Integrated Drug Discovery, Isotope Chemistry and Metabolite Synthesis; Sanofi; Frankfurt/Main Germany
2. Institut für Anorganische und Analytische Chemie; Technische Universität Braunschweig; Braunschweig Germany
Funder
European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie
Publisher
Wiley
Subject
Organic Chemistry,Spectroscopy,Drug Discovery,Radiology Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry
Reference47 articles.
1. Iridium compounds in catalysis;Crabtree;Acc Chem Res,1979
2. Deuteration of acetanilides and other substituted aromatics using [Ir(COD)(Cy3P)(Py)]PF6 as catalyst;Hesk;J Label Compd Radiopharm,1995
3. Highly active iridium(I) complexes for catalytic hydrogen isotope exchange;Brown;Chem Commun,2008
4. Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes;Cochrane;Org Biomol Chem,2014
5. C-H functionalization for hydrogen isotope exchange;Atzrodt;Angew Chem Int Ed
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